We are interested in molecular mechanisms that configure neural circuits to carry out computations. Our approach combines electrophysiological, molecular and behavioural analysis, with computational modeling and development of molecular and software tools. Current topics of interest include circuit mechanisms for encoding of location by the entorhinal cortex and hippocampus, and roles of ion channels in circuit computations important for behaviour. We hope that over the long term our research will be important for understanding and treating clinical disorders such as Alzheimer’s, schizophrenia, autism and epilepsy.